Pharmaceutical water purification systems
Water used in production processes for medical devices and pharmaceutical products must meet stringent standards. The pharmaceutical (medical/pharmaceutical) water systems must provide safe, high-quality water to meet your needs through an optimal combination of membrane separation technologies. Additionally, our experience ensures that our systems are highly reliable and economical for any use from purified water to injection water.
Purified water is used extensively as raw material, ingredient, solvent, or catalyst in the processing, formulation, and manufacturing of pharmaceutical products, active pharmaceutical ingredients (APIs) and intermediates, and analytical reagents.
Water reduces solid impurities and helps in attaining the level of chemical purity required to prevent pharmaceutical product contamination. Pharmaceutical industries prepare purified water using different purification methods. Three of the most common types of pharmaceutical water purification systems are:
- Ion exchange
- Reverse osmosis
- Distillation
Purified Water (Ion Exchange Water)
Abrah Co provides optimum water purification systems to meet the characteristics of different types of input (raw) water via a combination of technologies, The ion exchange method is one of the most commonly used water purification methods due to its minimal maintenance cost and ease of operation. pre-processing using reverse osmosis (RO) membranes, continuous regeneration ion exchange, and the conventional ion exchange resin method
Pyrogen-Free Water / Injection Water
Abrah co. is a comprehensive membrane engineering company with experience in organic and inorganic membranes.
Our sterile pyrogen-free/injection water systems are the culmination of our knowledge on design and clean technologies. In particular, our pyrogen-free sterilization technologies realize very safe and reliable systems.
Water Classification
| Input (raw) Water | Tap water or disinfected well water |
|---|---|
| Purified Water | Pure water where ions are removed from input water |
| Pyrogen-Free Water | Purified water where viable bacteria and pyrogens are removed using UF or other techniques |
| Injection Water | Injection water obtained by distilling purified water |
Water Quality Standards
| Water Control Item | Purified Water | Pyrogen-Free Water | Injection Water | |
|---|---|---|---|---|
| Conductivity (µS/cm, 20°C) |
≤1 | ≤1 | ≤1 | |
| Viable Bacteria Count (cfu/100ml) |
≤10,000 | ≤10 | ≤10 | |
| Endotoxin (EU/ml) |
- | ≤0.25 | ≤0.25 | |
| Insoluble Microparticles (count/ml) |
10µm or larger | - | - | ≤25 |
| 25µm or larger | - | - | ≤3 | |
| TOC(PPb) Off-line measurement |
≤500 | ≤500 | ≤500 | |
Wastewater treatment in the pharmaceutical industry
High-quality, purified water is critical in pharmaceutical manufacturing. Various methods such as reverse osmosis, carbon filtration, and aerobic/anaerobic treatment are employed for treating wastewater in pharmaceutical production plants. These are essential for the release or reuse of water in keeping with government guidelines to deal with water scarcity.
Various processes and technologies are adopted in the pharmaceutical industry for wastewater treatment. These include preliminary treatment, aeration, neutralisation, flocculation and coagulation, biological degradation, filtration, and recycling.
Water treatment and recycling technology providers need to understand the pharmaceutical industry’s requirements and the nature of their discharge to fulfil their requirements.